Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology

  title={Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology},
  author={Yohei Koshimizu and M. Ohtomi},
Leukocyte cell-derived chemotaxin 2 (LECT2) facilitates neuritic extension in cultured hippocampal neurons during initial development. However, the functions of LECT2 in neuritic extension are poorly understood. To elucidate these functions, we examined microtubular morphology and levels of katanin-P60, a microtubule-severing enzyme, in cultured hippocampal neurons from wild-type mice and LECT2 knockout (KO) mice. Microtubules in LECT2-KO mice exhibited fragmentation and were shorter than those… Expand
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Mechanistic models and regulations of microtubule severing by Katanin are highlighted in context of structure and various functions ofKatanin in different organisms. Expand
Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites
The findings suggest that LECT-2/Chondromodulin II acts as a muscle-derived, diffusible cofactor together with a skin-derived cell adhesion complex to orchestrate the molecular interactions of three tissues during patterning of somatosensory dendrites. Expand


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Regulation of Microtubule Severing by Katanin Subunits during Neuronal Development
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Increase in Hepatic NKT Cells in Leukocyte Cell-Derived Chemotaxin 2-Deficient Mice Contributes to Severe Concanavalin A-Induced Hepatitis1
The results suggest that LECT2 might regulate the homeostasis of NKT cells in the liver and might be involved in the pathogenesis of hepatitis. Expand
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Dynamic change in expression of LECT2 during liver regeneration after partial hepatectomy in mice.
Results indicate that LECT2 triggers the early events of regeneration with concomitant suppression of hepatocyte proliferation in mice after partial hepatectomy with significantly lower expression levels at 24 h after PHx. Expand
Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2.
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Katanin, a Microtubule-Severing Protein, Is a Novel AAA ATPase that Targets to the Centrosome Using a WD40-Containing Subunit
Microtubule disassembly at centrosomes is involved in mitotic spindle function. The microtubule-severing protein katanin, a heterodimer of 60 and 80 kDa subunits, was previously purified and shown toExpand
Two domains of p 80 katanin regulate microtubule severing and spindle pole targeting by p 60 katanin
Within the mitotic spindle, specific interactions between microtubules, chromosomes and numerous accessory proteins allow the generation of spatially regulated forces that bring about accurateExpand
Tubulin transport in neurons
It is shown that tubulin subunits, not microtubules, are the primary form of tubulin transport in neurons. Expand
Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF
Results indicate that released HB- EGF-C functions as an intracellular signal and coordinates cell cycle progression with HB-EGF. Expand