Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology

@article{Koshimizu2010RegulationOK,
  title={Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology},
  author={Yohei Koshimizu and M. Ohtomi},
  journal={NeuroReport},
  year={2010},
  volume={21},
  pages={646-650}
}
Leukocyte cell-derived chemotaxin 2 (LECT2) facilitates neuritic extension in cultured hippocampal neurons during initial development. However, the functions of LECT2 in neuritic extension are poorly understood. To elucidate these functions, we examined microtubular morphology and levels of katanin-P60, a microtubule-severing enzyme, in cultured hippocampal neurons from wild-type mice and LECT2 knockout (KO) mice. Microtubules in LECT2-KO mice exhibited fragmentation and were shorter than those… Expand
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