Regulation of ion channels by secreted Klotho: mechanisms and implications.

  title={Regulation of ion channels by secreted Klotho: mechanisms and implications.},
  author={C L Huang},
  journal={Kidney international},
  volume={77 10},
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choroid plexus of the brain. It is a single-pass transmembrane protein with a large extracellular domain. The extracellular domain of Klotho is cleaved and released into extracellular fluid, including blood, urine, and cerebrospinal fluid. The membrane-bound full-length Klotho and secreted extracellular domain of Klotho have distinct functions. Membrane Klotho interacts with fibroblast growth factor… CONTINUE READING
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