Regulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidism.

@article{Friedrichsen2003RegulationOI,
  title={Regulation of iodothyronine deiodinases in the Pax8-/- mouse model of congenital hypothyroidism.},
  author={Sönke Friedrichsen and Stephanie L. Christ and Heike Heuer and Martin K.-H. Sch{\"a}fer and Ahmed Mansouri and Karl -Heinz Bauer and Theo J. Visser},
  journal={Endocrinology},
  year={2003},
  volume={144 3},
  pages={
          777-84
        }
}
Thyroid hormones are essential for a variety of developmental and metabolic processes. Congenital hypothyroidism (CHT) results in severe defects in the development of different tissues, in particular brain. As an animal model for CHT, we studied Pax8(-/-) mice, which are born without a thyroid gland. We determined the expression of iodothyronine deiodinase D1 in liver and kidney, D2 in brain and pituitary, and D3 in brain, as well as serum T(4), T(3), and rT(3) levels in Pax8(-/-) vs. control… CONTINUE READING
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