Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine.

@article{EscobarMorreale1997RegulationOI,
  title={Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine.},
  author={H{\'e}ctor F Escobar-Morreale and Mar{\'i}a Jes{\'u}s Obreg{\'o}n and Aureliano Hern{\'a}ndez and Francisco Escobar del Rey and Gabriella Morreale de Escobar},
  journal={Endocrinology},
  year={1997},
  volume={138 6},
  pages={2559-68}
}
To provide new insights into the in vivo regulation of iodothyronine deiodinases in the different tissues of the rat, we have evaluated the effects on these enzymatic activities of T4 or T3 infusions into thyroidectomized rats. Thyroidectomized rats were infused with placebo, T4, or T3. Placebo-infused intact rats served as euthyroid controls. Plasma and samples of cerebral cortex, brown adipose tissue, pituitary, liver, and lung were obtained after 12-13 days of infusion. Plasma TSH, plasma… CONTINUE READING

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