Regulation of iodothyronine 5'-deiodination in lean and obese (ob/ob) mice.

@article{Hillgartner1985RegulationOI,
  title={Regulation of iodothyronine 5'-deiodination in lean and obese (ob/ob) mice.},
  author={F. Bradley Hillgartner and Dale R. Romsos},
  journal={The American journal of physiology},
  year={1985},
  volume={249 2 Pt 1},
  pages={E209-18}
}
Obese (ob/ob) mice exhibit impaired cold- and diet-induced thermogenesis, which may result in part from a defect in thyroid hormone action at the level of peripheral deiodination of thyroxine (T4) to 3,5,3'-triiodothyronine (T3). The latter possibility was examined by comparing kinetic parameters of 5'-deiodination (5'-D) in hepatic and renal microsomes of… CONTINUE READING