Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.

  title={Regulation of intrinsic axon growth ability at retinal ganglion cell growth cones.},
  author={Michael B Steketee and Carly Oboudiyat and Richard Daneman and Ephraim F Trakhtenberg and Philip Lamoureux and Jessica E Weinstein and Steve Heidemann and Ben A Barres and Jeffrey L. Goldberg},
  journal={Investigative ophthalmology & visual science},
  volume={55 7},
PURPOSE Mammalian central nervous system neurons fail to regenerate after injury or disease, in part due to a progressive loss in intrinsic axon growth ability after birth. Whether lost axon growth ability is due to limited growth resources or to changes in the axonal growth cone is unknown. METHODS Static and time-lapse images of purified retinal ganglion cells (RGCs) were analyzed for axon growth rate and growth cone morphology and dynamics without treatment and after manipulating Kruppel… CONTINUE READING
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