Regulation of intracellular pH in vertebrate central neurons

@article{Chesler1985RegulationOI,
  title={Regulation of intracellular pH in vertebrate central neurons},
  author={Mitchell Chesler and Charles Nicholson},
  journal={Brain Research},
  year={1985},
  volume={325},
  pages={313-316}
}
The regulation of intracellular pH (pHi) was investigated in reticulospinal neurons of the lamprey using ion-selective microelectrodes. Steady-state pHi in 23 mM HCO-3-buffered Ringer was 7.44 +/- 0.03 with a membrane potential of 54 +/- 4 mV (mean +/- S.E.M., n = 6). In nominally HCO-3-free solutions, pHi recovery from acid loading was blocked by 10(-3)M amiloride. Recovery was stimulated by transition to HCO-3-containing solutions. Results suggest that pHi regulation in lamprey reticulospinal… CONTINUE READING

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