Regulation of intracellular pH in human melanoma: potential therapeutic implications.

@article{Wahl2002RegulationOI,
  title={Regulation of intracellular pH in human melanoma: potential therapeutic implications.},
  author={Miriam L. Wahl and Judith A. Owen and Randy Burd and Robin A. Herlands and Suzanne S. Nogami and Ulrich Rodeck and David A. Berd and Dennis B. Leeper and Charles S. Owen},
  journal={Molecular cancer therapeutics},
  year={2002},
  volume={1 8},
  pages={617-28}
}
Melanoma cells in vivo maintain intracellular pH (pHi) in a viable range despite an extracellular tumor pH (pHe) that is typically below 7.0. In general, three families of transporters are capable of removing metabolic protons, but the specific transporters responsible for the maintenance of pHi at low pHe in melanomas have not been identified. Although the transporters exist in most cells, an inhibitor would be predicted to have selectivity for cells located in an acidic tumor bed because… CONTINUE READING