Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.

@article{Kang2007RegulationOI,
  title={Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.},
  author={Yeon-Joo Kang and Uri R Mbonye and Cynthia Delong and Masayuki Wada and William Leo Smith},
  journal={Progress in lipid research},
  year={2007},
  volume={46 2},
  pages={108-25}
}
Cyclooxygenases-1 and -2 (COX-1 and -2) catalyze the committed step in prostaglandin formation. Each isozyme subserves different biological functions. This is, at least in part, a consequence of differences in patterns of COX-1 and COX-2 expression. COX-1 is induced during development, and COX-1 mRNA and COX-1 protein are very stable. These latter properties can explain why COX-1 protein levels usually remain constant in those cells that express this isozyme. COX-2 is usually expressed… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS