Regulation of intracellular ceramide content in B16 melanoma cells. Biological implications of ceramide glycosylation.

@article{Komori1999RegulationOI,
  title={Regulation of intracellular ceramide content in B16 melanoma cells. Biological implications of ceramide glycosylation.},
  author={Hironobu Komori and Sohsuke Ichikawa and Yoshio Hirabayashi and Makoto Ito},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 13},
  pages={8981-7}
}
We previously reported that ceramide released from glycosphingolipids (GSLs) by endoglycoceramidase was directly metabolized to GSLs, and thus the content of GSLs was constantly maintained in B16 melanoma cells (Ito, M., and Komori, H. (1996) J. Biol. Chem. 271, 12655-12660). In this study, the metabolism of ceramide released from sphingomyelin (SM) by bacterial sphingomyelinase (SMase) was examined using B16 cells and their GSL-deficient mutant counterpart GM95 cells. Treatment of B16 melanoma… CONTINUE READING

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