Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ

  title={Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase I$\beta$},
  author={Jens Schlossmann and Aldo Ammendola and Keith Ashman and Xian-gang Zong and Andrea Huber and Gitte Neubauer and Ge‐Xin Wang and H D Allescher and Michael Korth and Matthias Wilm and Franz Hofmann and Peter Ruth},
Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells. Calcium release from inositol 1,4,5-trisphosphate (IP3)-sensitive stores is negatively regulated by binding of calmodulin to the IP3 receptor (IP3R) and the NO/cGMP/cGMP kinase I (cGKI) signalling pathway. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes… 

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The result confirm the concept that IRAG is an essential mediator of relaxation mediated by cGMP/cGK signalling in vascular smooth muscle.

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The regulation of PKG gene expression appears to be linked to phenotypic modulation of VSMC, and it is likely that changes in the activity of the nitric oxide/cGMP/PKG pathway is involved in the development of these diseases.

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Role of the Inositol 1,4,5-Trisphosphate Receptor in Ca2+ Feedback Inhibition of Calcium Release-activated Calcium Current (I crac)*

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