Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Iβ

@article{Schlossmann2000RegulationOI,
  title={Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase I$\beta$},
  author={Jens Schlossmann and Aldo Ammendola and Keith Ashman and Xian-gang Zong and Andrea Huber and Gitte Neubauer and Ge‐Xin Wang and H D Allescher and Michael Korth and Matthias Wilm and Franz Hofmann and Peter Ruth},
  journal={Nature},
  year={2000},
  volume={404},
  pages={197-201}
}
Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells. Calcium release from inositol 1,4,5-trisphosphate (IP3)-sensitive stores is negatively regulated by binding of calmodulin to the IP3 receptor (IP3R) and the NO/cGMP/cGMP kinase I (cGKI) signalling pathway. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes… 

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