Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets.

@article{Tsuura1999RegulationOI,
  title={Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets.},
  author={Yoshiyuki Tsuura and Shin-ichiro Fujimoto and Mizuho Kajikawa and Hitoshi Ishida and Yutaka Seino},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={261 2},
  pages={439-44}
}
ATP is the most important factor in glucose-induced insulin secretion in pancreatic beta-cells, but examination of intracellular differences in ATP concentration is difficult because ATP production and consumption occur simultaneously. In the present study, we measured the ATP concentration under the condition of a reduced ATP requirement by omitting extracellular Ca(2+) and inhibiting Na-K ATPase. The ATP concentration in islets incubated with 16.7 mM glucose in the absence of Ca(2+) for 30… CONTINUE READING

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