Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine.

@article{Stauber2005RegulationOI,
  title={Regulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine.},
  author={Annina Stauber and Tamara Radanovic and Gerti Stange and Heini Murer and Carsten A Wagner and Juerg Biber},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2005},
  volume={288 3},
  pages={G501-6}
}
During metabolic acidosis, P(i) serves as an important buffer to remove protons from the body. P(i) is released from bone together with carbonate buffering protons in blood. In addition, in the kidney, the fractional excretion of phosphate is increased allowing for the excretion of more acid equivalents in urine. The role of intestinal P(i) absorption in providing P(i) to buffer protons and compensating for loss from bone during metabolic acidosis has not been clarified yet. Inducing metabolic… CONTINUE READING

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