Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.

@article{Wilson1999RegulationOI,
  title={Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense.},
  author={Carole L. Wilson and Andr{\'e} Joseph Ouellette and Donald P. Satchell and Takuya Ayabe and Yolanda S. L{\'o}pez-Boado and Jennifer L. Stratman and Scott J Hultgren and Lynn M Matrisian and William C. Parks},
  journal={Science},
  year={1999},
  volume={286 5437},
  pages={113-7}
}
Precursors of alpha-defensin peptides require activation for bactericidal activity. In mouse small intestine, matrilysin colocalized with alpha-defensins (cryptdins) in Paneth cell granules, and in vitro it cleaved the pro segment from cryptdin precursors. Matrilysin-deficient (MAT-/-) mice lacked mature cryptdins and accumulated precursor molecules. Intestinal peptide preparations from MAT-/- mice had decreased antimicrobial activity. Orally administered bacteria survived in greater numbers… CONTINUE READING
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