Regulation of interleukin-6 production by prostaglandin E2 in fetal rat osteoblasts: role of protein kinase A signaling pathway.

@article{Millet1998RegulationOI,
  title={Regulation of interleukin-6 production by prostaglandin E2 in fetal rat osteoblasts: role of protein kinase A signaling pathway.},
  author={Ido Millet and Thomas L. McCarthy and Agn{\`e}s Vignery},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1998},
  volume={13 7},
  pages={1092-100}
}
Prostaglandin E2 (PGE2) is an abundant eicosanoid in bone that has been implicated in a number of pathological states associated with bone loss. Interleukin-6 (IL-6) is a cytokine that plays a critical role in bone remodeling and appears to act as a downstream effector of most bone-resorbing agents. In light of the evidence that PGE2 induces IL-6 in the bone environment, this study was designed to investigate whether PGE2 regulated IL-6 expression by osteoblasts. Here we demonstrate that PGE2… CONTINUE READING