Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase.

@article{Miyazawa1998RegulationOI,
  title={Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase.},
  author={Kohtaro Miyazawa and Akinori Mori and Hideki Aichi Miyata and Masaaki Akahane and Yukiyoshi Ajisawa and Hirokazu Okudaira},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 38},
  pages={
          24832-8
        }
}
Involvement of p38 mitogen-activated protein (MAP) kinase in interleukin (IL)-6 gene expression of human fibroblast-like synoviocytes (FLSs) was assessed. p38 MAP kinase was constitutively expressed in human FLSs and activated in response to IL-1beta. A pyridinylimidazole compound, SB203580, inhibited p38 MAP kinase activity in vivo, since the activity of MAPKAP kinase-2 (a substrate of p38 MAP kinase) in IL-1beta-stimulated FLSs was totally suppressed by it. SB203580 concentration-dependently… CONTINUE READING
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