Regulation of intercellular adhesion molecule-1 (CD54) gene expression.

  title={Regulation of intercellular adhesion molecule-1 (CD54) gene expression.},
  author={Kenneth A. Roebuck and Alison Finnegan},
  journal={Journal of leukocyte biology},
  volume={66 6},
Intercellular adhesion molecule-1 (ICAM-1, CD54) is an inducible cell adhesion glycoprotein of the immunoglobulin supergene family expressed on the surface of a wide variety of cell types. ICAM-1 interactions with the beta2 integrins CD11a/CD18 (LFA-1) and CD11b/CD18 (MAC-1) on the surface of leukocytes are important for their transendothelial migration to sites of inflammation and their function as costimulatory molecules for T cell activation. ICAM-1 is constitutively expressed on the cell… CONTINUE READING
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