Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells.

@article{Gioannini2007RegulationOI,
  title={Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells.},
  author={Theresa Lee Gioannini and Jerrold P Weiss},
  journal={Immunologic research},
  year={2007},
  volume={39 1-3},
  pages={
          249-60
        }
}
Host defense against many invading Gram-negative bacteria (GNB) depends on innate immune recognition of endotoxin (lipopolysaccharides, LPS), unique surface glycolipids of GNB. Host responses to endotoxin must be highly sensitive but self-limited. In mammals, optimal sensitivity is achieved by ordered interactions of endotoxin with several different extracellular and cell surface proteins-the LPS-binding protein (LBP), CD14, MD-2, and Toll-like receptor (TLR) 4-reflecting the requirement for… CONTINUE READING
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