Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.

  title={Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.},
  author={Zhuo Fu and Elizabeth R. Gilbert and Dongmin Liu},
  journal={Current diabetes reviews},
  volume={9 1},
Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism. Insulin is synthesized as preproinsulin and processed to proinsulin. Proinsulin is then converted to insulin and C-peptide and stored in secretary granules awaiting release on demand. Insulin synthesis is regulated at both the transcriptional and translational level. The cis-acting sequences within the 5… 

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  • Medicine, Biology
    International journal of molecular sciences
  • 2020
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