Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.

@article{Fu2013RegulationOI,
  title={Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.},
  author={Zhuo Fu and Elizabeth R. Gilbert and Dongmin Liu},
  journal={Current diabetes reviews},
  year={2013},
  volume={9 1},
  pages={
          25-53
        }
}
Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism. Insulin is synthesized as preproinsulin and processed to proinsulin. Proinsulin is then converted to insulin and C-peptide and stored in secretary granules awaiting release on demand. Insulin synthesis is regulated at both the transcriptional and translational level. The cis-acting sequences within the 5… 

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