Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).

@article{Destefano2013RegulationOI,
  title={Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2).},
  author={Michael A Destefano and Estela Jacinto},
  journal={Biochemical Society transactions},
  year={2013},
  volume={41 4},
  pages={
          896-901
        }
}
  • Michael A Destefano, Estela Jacinto
  • Published in
    Biochemical Society…
    2013
  • Biology, Medicine
  • mTOR (mammalian target of rapamycin) responds to the presence of nutrients, energy and growth factors to link cellular metabolism, growth and proliferation. The rapamycin-sensitive mTORC (mTOR complex) 1 activates the translational regulator S6K (S6 kinase), leading to increased protein synthesis in the presence of nutrients. On the other hand, the rapamycin-insensitive mTORC2 responds to the presence of growth factors such as insulin by phosphorylating Akt to promote its maturation and… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 50 REFERENCES

    mTOR in aging, metabolism, and cancer.

    Mammalian TOR signaling to the AGC kinases.