Regulation of insulin-like growth factor-binding proteins in rats with insulin-dependent diabetes mellitus.

@article{Rodgers1995RegulationOI,
  title={Regulation of insulin-like growth factor-binding proteins in rats with insulin-dependent diabetes mellitus.},
  author={B D Rodgers and Romeo M. Bautista and Charles S. Nicoll},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1995},
  volume={210 3},
  pages={234-41}
}
As previously reported, activation of the adrenocorticotropic hormone (ACTH)-adrenal cortical axis in rats with insulin-dependent diabetes mellitus (IDDM) reduces their growth and circulating insulin-like growth factor-I (IGF-I) levels and induces a resistance to growth hormone (GH) and IGF-I. The studies reported herein were conducted to determine whether the pituitary and/or adrenal gland influence the changes in basal and GH-stimulated serum concentrations of IGF-binding proteins (IGFBPs) in… CONTINUE READING