Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.

@article{Delafontaine1991RegulationOI,
  title={Regulation of insulin-like growth factor I messenger RNA levels in vascular smooth muscle cells.},
  author={Patrice Delafontaine and Huan Lou and Robert W. Alexander},
  journal={Hypertension},
  year={1991},
  volume={18 6},
  pages={742-7}
}
We have previously demonstrated specific insulin-like growth factor I (IGF I) messenger RNA (mRNA) transcripts in cultured rat aortic smooth muscle cells (RASM). To define the role of IGF I in the autocrine growth program of vascular smooth muscle cells, we quantitated IGF I mRNA levels in proliferating and quiescent (serum-deprived for 48 hours) RASM. IGF I mRNA levels were markedly decreased in quiescent cells, and this effect was reversible on reexposure to serum. Since platelet-derived… CONTINUE READING
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Hyper - tension induces insulin - like growth factor I gene expression in rat aorta ( abstract )

  • KA Fath, MC Hanson, P Delafontaine, RW Alexander
  • Circulation
  • 1990

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