Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue.

@article{Peter1993RegulationOI,
  title={Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue.},
  author={Mulenyi Peter and Kaspar H. Winterhalter and Marianne B{\"o}ni-Schnetzler and E. Rudolf Froesch and Juergen Zapf},
  journal={Endocrinology},
  year={1993},
  volume={133 6},
  pages={2624-31}
}
Insulin-like growth factor-I (IGF-I) mRNA levels in rat white adipose tissue (WAT) are in the same range as those in liver, the major source of serum IGF-I, and are far above the levels in other tissues. IGF-I mRNA and IGF-I peptide levels in WAT decrease drastically after hypophysectomy and are restored to near normal by GH treatment in vivo. IGF-I gene expression in WAT from hypophysectomized rats is also stimulated by GH in vitro; half-maximal stimulation of IGF-I mRNA occurs between 0.25-0… CONTINUE READING

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