Regulation of insulin gene transcription by the immediate-early growth response gene Egr-1.

@article{Eto2006RegulationOI,
  title={Regulation of insulin gene transcription by the immediate-early growth response gene Egr-1.},
  author={Kazuhiro Eto and Varinderpal Kaur and Melissa K. Thomas},
  journal={Endocrinology},
  year={2006},
  volume={147 6},
  pages={
          2923-35
        }
}
Changes in extracellular glucose levels regulate the expression of the immediate-early response gene and zinc finger transcription factor early growth response-1 (Egr-1) in insulin-producing pancreatic beta-cells, but key target genes of Egr-1 in the endocrine pancreas have not been identified. We found that overexpression of Egr-1 in clonal (INS-1) beta-cells increased transcriptional activation of the rat insulin I promoter. In contrast, reductions in Egr-1 expression levels or function with… CONTINUE READING
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