Regulation of insulin exocytosis by Munc13-1.

@article{Sheu2003RegulationOI,
  title={Regulation of insulin exocytosis by Munc13-1.},
  author={Laura Sheu and Eva A Pasyk and Junzhi Ji and Xiaohang Huang and Xiaodong Gao and Frederique Varoqueaux and Nils Brose and Herbert Y Gaisano},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 30},
  pages={27556-63}
}
The slower kinetics of insulin release from pancreatic islet beta cells, as compared with other regulated secretory processes such as chromaffin granule secretion, can in part be explained by the small number of the insulin granules that are docked to the plasma membrane and readily releasable. In type-2 diabetes, the kinetics of insulin secretion become grossly distorted, and, to therapeutically correct this, it is imperative to elucidate the mechanisms that regulate priming and secretion of… CONTINUE READING
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