Regulation of insulin biosynthesis in non-beta cells by a heat shock promoter.

Abstract

Insulin production under the stringent control is the main issue in gene-based therapeutic strategies directed to type 1 diabetes. As a novel approach, inducible promoters may provide a promising tool for this purpose. In this study, we hypothesize that this control may be achieved via a promoter derived from the heat shock multigene family, Hsp70 A1A… (More)
DOI: 10.1016/j.jbiosc.2013.02.014

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