Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae.

@article{Ye2013RegulationOI,
  title={Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae.},
  author={Cunqi Ye and Wachindra Bandara and Miriam L Greenberg},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 34},
  pages={
          24898-908
        }
}
Although inositol pyrophosphates have diverse roles in phosphate signaling and other important cellular processes, little is known about their functions in the biosynthesis of inositol and phospholipids. Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism. Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and… CONTINUE READING
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