Regulation of inositol lipid kinases by Rho and Rac.

@article{Ren1998RegulationOI,
  title={Regulation of inositol lipid kinases by Rho and Rac.},
  author={X D Ren and Martin A Schwartz},
  journal={Current opinion in genetics & development},
  year={1998},
  volume={8 1},
  pages={
          63-7
        }
}
Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho and/or Rac. Rho family GTPases also interact with phosphatidylinositol 3-kinase, though this kinase… CONTINUE READING

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