Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor.


Inositol 1,4,5-trisphosphate (Ins-1,4,5-P3), a Ca2+-mobilizing messenger, can be phosphorylated by a cytoplasmic kinase, yielding inositol 1,3,4,5-tetrakisphosphate (Ins-1,3,4,5-P3). We observed that stimulation of the antigen receptor on a malignant human T cell line, Jurkat, led to substantial, sustained increases in Ins-1,4,5-P3 and InsP4. The Ins-1,4,5… (More)


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