Regulation of innate immune responses in the central nervous system.

@article{Bajramovic2011RegulationOI,
  title={Regulation of innate immune responses in the central nervous system.},
  author={Jeffrey J Bajramovic},
  journal={CNS & neurological disorders drug targets},
  year={2011},
  volume={10 1},
  pages={4-24}
}
Innate immune responses in the central nervous system must be tightly regulated as unrestrained activation generates a chronic inflammatory environment that can contribute to neurodegeneration and autoimmunity. Microglia express a wide variety of receptors of the innate immune system and are competent responders to danger. Toll-like receptor-, NOD-like receptor- and RIG1-like receptor-mediated activation of microglia leads to the production of pro-inflammatory cytokines and to the upregulation… CONTINUE READING

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