Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.

@article{Wang2008RegulationOI,
  title={Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules.},
  author={Zhichao Wang and Myoung Kwon Choi and Tatsuma Ban and Hideyuki Yanai and Hideo Negishi and Yan Lu and Tomohiko Tamura and Akinori Takaoka and Kazuko Nishikura and T. Taniguchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 14},
  pages={5477-82}
}
DNA, whether it is microbe-derived or host-derived, evokes immune responses when exposed to the cytosol of a cell. We previously reported that DNA-dependent activator of IFN regulatory factors (DAI), also referred to as DLM-1/ZBP1, functions as a DNA sensor that activates the innate immune system. In the present study, we examined the regulation of the complex DNA-sensing system by DAI and other molecules. We first show that DAI directly interacts with DNA in vitro and that it requires three… CONTINUE READING
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