Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.

Abstract

RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs). RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of IFN-alpha/beta immune defenses that impact cell permissiveness for hepatitis C virus (HCV). Here we evaluated the processes that control RIG-I signaling. RNA binding studies and… (More)

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Cite this paper

@article{Saito2007RegulationOI, title={Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.}, author={Takeshi Saito and Reiko Hirai and Yueh-Ming Loo and David Owen and Cynthia L. Johnson and Sangita C Sinha and Shizuo Akira and Takashi Fujita and Michael Gale}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 2}, pages={582-7} }