Regulation of innate and adaptive immunity by Notch

  title={Regulation of innate and adaptive immunity by Notch},
  author={Freddy Radtke and H Robson Macdonald and Fabienne Tacchini-Cottier},
  journal={Nature Reviews Immunology},
Coordinated function of the innate and adaptive arms of the immune system in vertebrates is essential to promote protective immunity and to avoid immunopathology. The Notch signalling pathway, which was originally identified as a pleiotropic mediator of cell fate in invertebrates, has recently emerged as an important regulator of immune cell development and function. Notch was initially shown to be a key determinant of cell-lineage commitment in developing lymphocytes, but it is now known to… CONTINUE READING