Regulation of innate CD8+ T-cell activation mediated by cytokines.

  title={Regulation of innate CD8+ T-cell activation mediated by cytokines.},
  author={Bailey E Freeman and Erika K Hammarlund and H P Rau{\'e} and Mark K. Slifka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 25},
Virus-specific CD8(+) T cells develop the ability to function in an "innate" capacity by responding to a remarkable array of cytokines in a TCR-independent manner. Although several cytokines such as IL-12 and IL-18 have been identified as key regulators of CD8(+) T-cell activation, the role of other cytokines and the ways in which they interact with each other remain unclear. Here, we have used an unbiased, systematic approach to examine the effects of 1,849 cytokine combinations on virus… CONTINUE READING


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