Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation.

@article{Turrell2015RegulationOI,
  title={Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation.},
  author={Lauren Turrell and Edward C Hutchinson and Frank T. Vreede and Ervin Fodor},
  journal={Journal of virology},
  year={2015},
  volume={89 2},
  pages={1452-5}
}
In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule and the groove of the neighboring molecule. In this study, we show that phosphorylation of a serine residue (S165) within the groove of influenza A virus nucleoprotein inhibits oligomerization and, consequently, ribonucleoprotein activity and viral growth. We propose that nucleoprotein oligomerization in infected cells is regulated by… CONTINUE READING
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