Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.

@article{LunaMedina2005RegulationOI,
  title={Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.},
  author={Rosario Luna-Medina and Marta Cort{\'e}s-Canteli and Mercedes Alonso and Angel Santos and Ana Beatriz Martinez and Ana Perez-Castillo},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 22},
  pages={21453-62}
}
In most neurodegenerative disorders, including multiple sclerosis, Parkinson disease, and Alzheimer disease, a massive neuronal cell death occurs as a consequence of an uncontrolled inflammatory response, where activated astrocytes and microglia and their cytotoxic agents play a crucial pathological role. Current treatments for these diseases are not effective. In the present study we investigate the effect of thiadiazolidinone derivatives, which have been recently suggested to play a role in… CONTINUE READING

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