Regulation of inflammation by the antioxidant haem oxygenase 1.

  title={Regulation of inflammation by the antioxidant haem oxygenase 1.},
  author={Nicole K Campbell and Hannah K Fitzgerald and Aisling Dunne},
  journal={Nature reviews. Immunology},
Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of haem, is primarily considered an antioxidant, and has long been overlooked by immunologists. However, research over the past two decades in particular has demonstrated that HO-1 also exhibits numerous anti-inflammatory properties. These emerging immunomodulatory functions have made HO-1 an appealing target for treatment of diseases characterized by high levels of chronic inflammation. In this Review, we present an… 

The different facets of heme-oxygenase 1 in innate and adaptive immunity

This review focuses on the interplay between HO-1 and immune-related signaling pathways, which culminate in the activation of transcription factors important in immune responses and inflammation.

Heme Oxygenase-1: An Anti-Inflammatory Effector in Cardiovascular, Lung, and Related Metabolic Disorders

Evidence from human studies indicate that HO-1 expression may represent a biomarker of oxidative stress in various clinical conditions, while increases in serum BR levels have been correlated inversely to risk of CVD and metabolic disease.

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

In-depth analysis showed that hemin significantly modified the immune system in both spleen and peripheral blood, suggesting that modulating HO-1 signaling represents a potential therapeutic strategy against atherosclerosis.

Association between HO-1 gene promoter polymorphisms and diseases

Progress that has been made in research on the association between the two types of polymorphisms and these diseases is reviewed, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases.

Potential Implications of Rimonabant on Age-Related Oxidative Stress and Inflammation

These findings prove the beneficial involvement of CB1 receptor blocker rimonabant on inflammatory and oxidative damages to the aging heart through boosting of the antioxidant defense mechanisms as regards the HO system, and the SOD and glutathione content.

Inhibition of Heme Oxygenase-1 by Zinc Protoporphyrin IX Improves Adverse Pregnancy Outcomes in Malaria During Early Gestation

It is found that malaria affected the pregnancy outcome in the three periods evaluated, but only poor pregnancy outcomes in early pregnancy were related to HO-1 upregulation, iron overload, lipid peroxidation and necrosis of the decidua, which were prevented by HO- 1 inhibition.

A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes

Three small subsets of 1,5-diarylpyrrole and pyrazole dicobalt(0)hexacarbonyl (DCH)-CORMs were developed and showed an improvement in tendon homeostasis and a cytoprotective effect, reflecting their activity as CO-releasers, and a reduction of PGE2 secretion.

The role of itaconate in host defense and inflammation

Itaconate and its derivatives have antiinflammatory effects in preclinical models of sepsis, viral infections, psoriasis, gout, ischemia/reperfusion injury, and pulmonary fibrosis, pointing to possible itaconate-based therapeutics for a range of inflammatory diseases.

Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers

The importance of HO-1 as a therapeutic target for diabetic wound healing is discussed, in part mediated through the biologically active end products generated by its enzymatic activity, particularly CO, BV, and BR.

Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders

  • S. Ryter
  • Biology
    International journal of molecular sciences
  • 2021
Therapeutic strategies targeting the heme/HO-1 pathway, including therapeutic modulation of heme levels, elevation (or inhibition) of HO-1 protein and activity, and application of CO donor compounds or gas show potential in inflammatory conditions including sepsis and pulmonary diseases.



Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.

  • S. RyterA. Choi
  • Biology
    Translational research : the journal of laboratory and clinical medicine
  • 2016

Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

It is concluded that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health and opens a new outlook on the investigation of naturally derivedHO-1 inducers, mainly concerning autoimmunity.

The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1.

Heme oxygenase-1 expression appears to regulate the homeostatic activity and distribution of mononuclear phagocytes in lymphoid tissue under physiological conditions and regulates the ability of MP to modulate the inflammatory response to tissue injury.

Heme Oxygenase-1 Expression in Macrophages Plays a Beneficial Role in Atherosclerosis

It is concluded that HO-1 expression in macrophages constitutes an important component of the antiatherogenic effect by increasing antioxidant protection and decreasing the inflammatory component of atherosclerotic lesions.

Inducers of heme oxygenase-1.

The purpose of this article is to review the increasing number of natural and synthetic molecules reported to induce HO-1 as additive mechanism responsible for their therapeutic effects; experimental and pathological conditions as well as possible signalling mechanism involved inHO-1 expression by this compounds are described.

Heme oxygenase-1 plays an important protective role in experimental autoimmune encephalomyelitis

The results suggest that endogenous HO-1 plays an important protective role in EAE, and that targeted induction ofHO-1 overexpression may represent a new therapy for the treatment of multiple sclerosis.

Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?

The expression of the two HO isoenzymes, HO-1 and HO-2, during the healing process of full-thickness excisional wounds in mice is determined and a novel role for HO might be involved in haem degradation and in the protection of cells from the toxic effects of ROS is suggested.

Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production

It is demonstrated that myeloid HO-1 is required for the activation of interferon (IFN) regulatory factor (IRF) 3 after Toll-like receptor 3 or 4 stimulation, or viral infection, and that these defects were rectified by exogenous administration of IFN-β, confirming thatHO-1 functions directly upstream of this critical immune pathway.