Regulation of inflammation by the antioxidant haem oxygenase 1.

@article{Campbell2021RegulationOI,
  title={Regulation of inflammation by the antioxidant haem oxygenase 1.},
  author={Nicole K Campbell and Hannah K Fitzgerald and Aisling Dunne},
  journal={Nature reviews. Immunology},
  year={2021}
}
Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of haem, is primarily considered an antioxidant, and has long been overlooked by immunologists. However, research over the past two decades in particular has demonstrated that HO-1 also exhibits numerous anti-inflammatory properties. These emerging immunomodulatory functions have made HO-1 an appealing target for treatment of diseases characterized by high levels of chronic inflammation. In this Review, we present an… 

The different facets of heme-oxygenase 1 in innate and adaptive immunity

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Progress that has been made in research on the association between the two types of polymorphisms and these diseases is reviewed, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases.

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Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders

  • S. Ryter
  • Biology
    International journal of molecular sciences
  • 2021
Therapeutic strategies targeting the heme/HO-1 pathway, including therapeutic modulation of heme levels, elevation (or inhibition) of HO-1 protein and activity, and application of CO donor compounds or gas show potential in inflammatory conditions including sepsis and pulmonary diseases.
...

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