Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.

@article{Togni2005RegulationOI,
  title={Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.},
  author={Mauro Togni and Kenneth D. Swanson and Sibylle Reimann and Stefanie Kliche and Andrew C. Pearce and Luca Simeoni and Dirk Reinhold and J{\"u}rgen Wienands and Benjamin G Neel and Burkhart Schraven and Annegret Gerber},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 18},
  pages={8052-63}
}
SKAP-HOM is a cytosolic adaptor protein representing a specific substrate for the Src family protein tyrosine kinase Fyn. Previously, several groups have provided experimental evidence that SKAP-HOM (most likely in cooperation with the cytosolic adaptor protein ADAP) is involved in regulating leukocyte adhesion. To further assess the physiological role of SKAP-HOM, we investigated the immune system of SKAP-HOM-deficient mice. Our data show that T-cell responses towards a variety of stimuli are… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Similar Papers

Loading similar papers…