Regulation of in situ to invasive breast carcinoma transition.

  title={Regulation of in situ to invasive breast carcinoma transition.},
  author={M Hu and Jun Yao and Danielle K. Carroll and Stanislawa Weremowicz and H Chen and Daniel Carrasco and Andrea Richardson and Shelia M. Violette and Tatiana Nikolskaya and Yuri Nikolsky and Erica L. Bauerlein and William C. Hahn and Rebecca S. Gelman and Craig P Allred and Mina J. Bissell and Stuart Schnitt and Korn{\'e}lia Poly{\'a}k},
  journal={Cancer cell},
  volume={13 5},
The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate… CONTINUE READING
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Gene description, and Cellular localization are listed. In the SAGE library names N-normal, DDCIS, and I-invasive ductal carcinoma

  • L. Cai, H. Huang, S. Blackshaw, J. S. Liu, C. Cepko, W. H. Wong
  • Genome Biol
  • 2004
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