Regulation of immunity in Trypanosoma cruzi infection.

  title={Regulation of immunity in Trypanosoma cruzi infection.},
  author={Rick L. Tarleton},
  journal={Experimental parasitology},
  volume={73 1},
Immunity to T. cruzi is complex, involving among other components, antibody production, CD4+ helper cells, CD8+ T cells as both regulators and effectors of immunity, and possibly, double-negative T cells. In addition, several of these components have been implicated in pathogenesis in the chronic infection. Although the immunosuppression observed in the infection seems quite severe, it also appears to provide for a sufficient level of immune responsiveness to control the infection in most hosts… CONTINUE READING