Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.

  title={Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.},
  author={Edward J. Goetzl and H. K. Rosen},
  journal={The Journal of clinical investigation},
  volume={114 11},
T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections… CONTINUE READING
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Expression and function of the type 1 sphingosine 1-phosphate receptor (S1P1-R) in immunity

  • M. H. Graler, E. J. Goetzl
  • In International Proceedings of Immunology
  • 2004
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