Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate

  title={Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate},
  author={Karsten Sauer and Michael P. Cooke},
  journal={Nature Reviews Immunology},
The membrane lipid phosphatidylinositol-3,4,5-trisphosphate (PtdInsP3) regulates membrane receptor signalling in many cells, including immunoreceptor signalling. Here, we review recent data that have indicated essential roles for the soluble PtdInsP3 analogue inositol-1,3,4,5-tetrakisphosphate (InsP4) in T cell, B cell and neutrophil development and function. Decreased InsP4 production in leukocytes causes immunodeficiency in mice and might contribute to inflammatory vasculitis in Kawasaki… CONTINUE READING


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