Regulation of immune and autoimmune responses by ICOS-B7h interaction.

@article{Nurieva2005RegulationOI,
  title={Regulation of immune and autoimmune responses by ICOS-B7h interaction.},
  author={Roza Nurieva},
  journal={Clinical immunology},
  year={2005},
  volume={115 1},
  pages={
          19-25
        }
}
Proper T cell activation and function are regulated by the innate immune system, importantly through positive and negative costimulatory molecules of the B7 superfamily. Inducible costimulator (ICOS) is expressed on T cells after T cell activation. A ligand for ICOS, B7h (also known as B7RP-1), is expressed on B cells and induced in nonlymphoid tissues by TNF-alpha. The wide distribution of B7h may play essential roles in different phases and types of immune function. In this review, we… CONTINUE READING
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