Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

Abstract

There are a large number of Rho guanine nucleotide exchange factors, most of which have no known functions. Here, we carried out a short hairpin RNA-based functional screen of Rho-GEFs for their roles in leukocyte chemotaxis and identified Arhgef5 as an important factor in chemotaxis of a macrophage phage-like RAW264.7 cell line. Arhgef5 can strongly… (More)
DOI: 10.1074/jbc.M109.047282

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Cite this paper

@article{Wang2009RegulationOI, title={Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.}, author={Zhenglong Wang and Yosuke Kumamoto and Ping Wang and Xiaoqing Gan and David M. Lehmann and Alan V. Smrcka and Lauren Cohn and Akiko Iwasaki and Lin Li and Dianqing Wu}, journal={The Journal of biological chemistry}, year={2009}, volume={284 42}, pages={28599-606} }