Regulation of iNOS by the p44/42 mitogen-activated protein kinase pathway in human melanoma

Abstract

Activating mutations of the genes for NRAS and BRAF, components of the p44/42 mitogen-activated protein kinase (MAPK) pathway, are common findings in melanoma. Recent evidence in several nonmelanoma cell systems supports the regulation of the inducible nitric oxide synthase (iNOS) gene by this pathway. On the basis of our data showing that melanoma iNOS… (More)
DOI: 10.1038/sj.onc.1209419

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@article{Ellerhorst2006RegulationOI, title={Regulation of iNOS by the p44/42 mitogen-activated protein kinase pathway in human melanoma}, author={Julie A. Ellerhorst and Suhendan Ekmekcioglu and Martin K. Johnson and Carolyn P. Cooke and Melyssa M Johnson and E. A. Grimm}, journal={Oncogene}, year={2006}, volume={25}, pages={3956-3962} }