Regulation of iNOS by the p44/42 mitogen-activated protein kinase pathway in human melanoma

  title={Regulation of iNOS by the p44/42 mitogen-activated protein kinase pathway in human melanoma},
  author={Julie A. Ellerhorst and Suhendan Ekmekcioglu and Marilyn K Johnson and Carolyn P Cooke and Melissa M. Johnson and Elizabeth Ann Grimm},
Activating mutations of the genes for NRAS and BRAF, components of the p44/42 mitogen-activated protein kinase (MAPK) pathway, are common findings in melanoma. Recent evidence in several nonmelanoma cell systems supports the regulation of the inducible nitric oxide synthase (iNOS) gene by this pathway. On the basis of our data showing that melanoma iNOS expression predicts shortened patient survival, we formulated the hypothesis that activating mutations of NRAS or BRAF, which lead to… CONTINUE READING


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