Regulation of hypothalamic somatostatin, growth hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids.

@article{Sears1996RegulationOH,
  title={Regulation of hypothalamic somatostatin, growth hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids.},
  author={Rosa Se{\~n}ar{\'i}s and Francisca Lago and R Coya and Julia Pineda and Carlos Di{\'e}guez},
  journal={Endocrinology},
  year={1996},
  volume={137 12},
  pages={5236-41}
}
Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secretion, and action. In this work, we evaluated the effect of dexamethasone on hypothalamic somatostatin and GH-releasing hormone (GHRH) messenger RNA (mRNA) levels by in situ… CONTINUE READING
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