Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.

  title={Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.},
  author={S M Kim and Jae W Yang and Mi Jung Park and J K Lee and Seung Up Kim and Young Seek Lee and Myung Ae Lee},
  journal={Biochemical and biophysical research communications},
  volume={346 2},
Tyrosine hydroxylase (TH), the biosynthetic enzyme of catecholamine, is synthesized specifically in catecholaminergic neurons. Thus, it is possible that neuronal cell type-specific expression of this gene is coordinately regulated. One of the neuron-specific transcription regulators, neuron-restrictive silencer factor (NRSF)/repressor element 1 (RE1) silencing transcription factor (REST), represses the expression of neuronal genes in non-neuronal cells. To elucidate the molecular mechanisms… CONTINUE READING


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