Regulation of human sperm motility and hyperactivation components by calcium, calmodulin, and protein phosphatases.

@article{Ahmad1995RegulationOH,
  title={Regulation of human sperm motility and hyperactivation components by calcium, calmodulin, and protein phosphatases.},
  author={Khorshidi Ahmad and G E Bracho and Don P Wolf and Joseph S Tash},
  journal={Archives of andrology},
  year={1995},
  volume={35 3},
  pages={187-208}
}
The role of Ca2+, calmodulin, and protein phosphatases on motility and hyperactivation of noncapacitated, capacitating, and detergent-permeabilized reactivated human sperm was examined. In noncapacitated sperm, W7 inhibited percent motility (%MOT), curvilinear velocity (VCL), amplitude of lateral head displacement (ALH), and percent hyperactivation (%HYP) in an extracellular Ca2+ concentration-dependent manner (p < .05). However, in capacitating sperm, inhibition of motility by W7 was… CONTINUE READING

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