Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site

@article{Chung2005RegulationOH,
  title={Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site},
  author={S. Chung and H. Choi and K. Kim and Y. Cho and H. Lee and K. Park},
  journal={Diabetologia},
  year={2005},
  volume={48},
  pages={1150-1158}
}
  • S. Chung, H. Choi, +3 authors K. Park
  • Published 2005
  • Biology, Medicine
  • Diabetologia
  • Aims/hypothesisResistin is an adipokine that might link obesity and insulin resistance. A common polymorphism of the human resistin gene, −420C>G, is a major determinant of plasma resistin concentrations as well as resistin mRNA expression in human adipose tissue. In this study, we investigated the regulatory mechanism by which this polymorphism affects resistin expression.MethodsElectrophoretic mobility shift assay was performed to identify the transcription factors binding to the −420G region… CONTINUE READING
    Resistin- and Obesity-associated metabolic diseases.
    • 159
    • PDF

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